Cellular interactions in bovine tuberculosis: release of active mycobacteria from infected macrophages by antigen-stimulated T cells
نویسندگان
چکیده
منابع مشابه
Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration.
Mycobacterium tuberculosis infection is characterized by a strong inflammatory response whereby a few infected macrophages within the granuloma induce sustained cellular accumulation. The mechanisms coordinating this response are poorly characterized. We hypothesized that microparticles (MPs), which are submicron, plasma membrane-derived vesicles released by cells under both physiological and p...
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Activation of both CD4(+) and CD8(+) T cells is required for an effective immune response to an M. tuberculosis infection. However, infected macrophages are poor antigen presenting cells and may be spatially separated from recruited T cells, thus limiting antigen presentation within a granuloma. Our previous studies showed that infected macrophages release from cells small membrane-bound vesicl...
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ژورنال
عنوان ژورنال: Immunology
سال: 2000
ISSN: 0019-2805
DOI: 10.1046/j.1365-2567.2000.00930.x